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SKI II
CAS No. 312636-16-1
SKI II ( SKI-II; SKI II. Sphingosine kinase inhibitor II )
Catalog No. M18409 CAS No. 312636-16-1
SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 51 | In Stock |
|
| 25MG | 97 | In Stock |
|
| 50MG | 168 | In Stock |
|
| 100MG | 294 | In Stock |
|
| 200MG | 530 | In Stock |
|
| 500MG | 849 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSKI II
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NoteResearch use only, not for human use.
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Brief DescriptionSKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
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DescriptionSKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells.
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SynonymsSKI-II; SKI II. Sphingosine kinase inhibitor II
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PathwayOthers
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TargetOther Targets
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RecptorSphK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number312636-16-1
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Formula Weight302.78
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Molecular FormulaC15H11ClN2OS
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Purity98%
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SolubilityDMSO : ≥ 100 mg/mL; 330.27 mM
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SMILESc1cc(ccc1c1csc(n1)Nc1ccc(cc1)O)Cl
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Chemical Name4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. French KJ, et al. Y Res, 2003, 63(18), 5962-5969.
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